The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Mom discovers son kneeling in prayer in Walmart
One day, young Braydon went shopping with his mother at the large US grocery store Walmart. But it wasn’t long before his mother became frightened when she discovered Braydon had vanished.
His mother found him after frantic, terrified searching for a few minutes.
Her initial thought was to chastise him for abandoning her. Yet she paused to consider why when she noticed him kneeling and praying in front of a sign board. She then looked at the wall more closely.
The worst nightmare of any parent is losing a child, even if it’s just temporarily. It is, of course, not unusual, particularly in areas with high pedestrian traffic, such shopping centers and huge grocery shops. At least for Braydon’s mother. She was eager to finish her shopping at Walmart, one of the biggest and busiest retail companies in the world, as soon as possible.
Faith Tap reports that Braydon’s mother stated, “I had to run into Walmart.” I looked back to make sure my son was by my side.
But he wasn’t. In a matter of moments, Braydon had plotted to distance himself from his mother.
When she finally located him, Braydon was knelt in front of a sign. He was in prayer. She asked him what he was doing since she was taken aback. But as she drew nearer to the board and looked, she was able to make sense of her son’s behavior.
It said, “Every second counts,” on the board. There were photographs of missing children next to those words. After seeing the board and leaving his mother’s side, little Braydon prayed to God that the kids would go back to their homes.
The heartwarming picture and the narrative that went with it went popular on the internet very fast. After seeing Braydon’s tale, the Facebook page for Aubrey Jayce Carroll, an adolescent boy who has been missing since 2016, made the decision to write a tribute to him.
“I would like to thank you for your prayers for these children, even if I am not sure who this little guy is. Aubrey Carroll is one of my cousins out there. I’m definitely impacted by this. I would love to thank this child in person if I knew where he was or who he was.
Since then, Facebook users have shared the picture of Braydon kneeling in front of the board more than 115,000 times.
You will agree that 800,000 or more children in the US are reported missing each year, according to the National Center for Missing and Exploited Children.
It’s best summarized by a Facebook commentator on the image: “It truly doesn’t matter whether or not you believe in God. This young person in Walmart was thinking of other people and trying to help as much as he could. If more people emulated him, the world would be a better place.
Well done, mom! You’re doing something right—foundation is essential!
Bless his heart, God. I adore how deeply his faith permeates his consciousness.
If you agree, then like and share this article on Facebook! Join us in our efforts to improve the world.
Leave a Reply