The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
How did Austria’s “most beautiful artificial girl” appear before her transformation
To begin, let’s revisit a bit of history. The first Barbie doll was released in 1959, marketed as the epitome of anatomical perfection. Unlike the traditional big-eyed celluloid dolls, Barbie’s adult face and feminine figure offered a fresh alternative, quickly captivating young girls. However, as time passed, concerns arose. Doctors warned of the doll’s unintended influence, as teenage girls began striving for its unattainable proportions. Barbie became linked to cases of anorexia, affecting hundreds, if not thousands, worldwide.
While browsing for fashion inspiration this season, I stumbled upon an article praising an Austrian Barbie-inspired figure as a style icon. Yet, finding accurate information about her proved challenging.
Meet Billie (or Anna, depending on the source), a 30-year-old Vienna resident who describes herself as a style icon and “Europe’s most beautiful artificial woman.” Born in 1994 into an ordinary family, Billie had a typical childhood, attending school and playing sports without any standout interests. During her teenage years, she embraced the emo subculture, dyeing her hair black, getting piercings, and later adding tattoos.
At 18, Billie grew disenchanted with the emo aesthetic, realizing it wasn’t garnering the attention she craved. This epiphany led her to transform her image, trading dark tones for the pastel hues of babydoll pink. Although her new look attracted more notice, Billie still felt inadequate. At 19, she underwent her first breast augmentation, beginning a journey of self-reinvention that would define her public persona.
Billie’s rise to fame was gradual. Initially, she earned money by sharing photos on various online platforms, receiving payments based on views. She even claims to have been among the early pioneers of OnlyFans, though this assertion remains unverified.
Over time, Billie caught the media’s attention, making appearances on television and talk shows where she shared stories about her life and transformation. Before her drastic changes, she was a naturally attractive young woman with striking eyes. However, Billie admitted she saw little beauty in her original appearance, opting instead for cosmetic surgery to fit societal trends and ideals.
Despite her fame, Billie has acknowledged her dependency on plastic surgeries and cosmetic injections. While she recognizes her addiction, she feels unable—and perhaps unwilling—to change course. Her story serves as a poignant reflection of the lengths some go to in pursuit of beauty and acceptance.
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