The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
Why You Should Sleep With Garlic Under Your Pillow
Garlic has been used for centuries, not just in cooking, but also for its powerful medicinal properties. One surprising yet ancient practice is placing garlic under your pillow while you sleep. While it might sound unusual, there are several reasons why this tradition has stuck around, offering benefits for both sleep quality and overall health.
1. Promotes Relaxation and Better Sleep
Garlic contains sulfur compounds that emit a calming aroma when placed under your pillow. This natural scent helps to relax the mind and body, making it easier to fall asleep and stay asleep. If you struggle with insomnia or restless nights, this simple remedy can promote deeper and more restful sleep.
2. Boosts Immunity
Garlic is known for its immune-boosting properties, thanks to its high concentration of allicin, an active compound that fights off bacteria and viruses. While placing garlic under your pillow won’t directly enter your system like eating it, the scent may help create a protective barrier against airborne illnesses during cold and flu season.
3. Clears Nasal Passages
If you’re prone to congestion or sinus problems, garlic can help. The strong scent of garlic may act as a natural decongestant, helping to clear nasal passages and make breathing easier. This can be particularly helpful if you suffer from allergies or seasonal colds that affect your sleep.
4. Repels Insects
Garlic’s strong odor is not only unpleasant for bugs but also acts as a natural repellent for mosquitoes and other insects. Placing garlic under your pillow may keep unwanted pests away while you sleep, creating a more peaceful and uninterrupted rest.
5. Provides Spiritual Benefits
In various cultures and traditions, garlic has been used to ward off negative energy, evil spirits, and bad dreams. While these beliefs may be more symbolic than scientific, many people still practice sleeping with garlic as a way to create a sense of protection and safety during the night.
How to Use Garlic Under Your Pillow
- Peel a clove of garlic and place it under your pillow before going to bed. You can also crush the garlic slightly to release more of its aroma.
- For an added boost, place the garlic in a small sachet or cloth to keep your pillow clean while still allowing the scent to flow.
- Replace the garlic every few days to maintain its potency.
Final Thoughts
Sleeping with garlic under your pillow is a natural remedy that can help promote relaxation, improve sleep quality, boost immunity, and keep insects at bay. Whether you’re looking to improve your health or try an ancient practice for better rest, this simple trick is worth a try!
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