Vaccines have played a crucial role in combating the Covid-19 pandemic, helping to prevent severe illness and death. However, in an extremely rare case, a Covid booster shot reactivated tuberculosis (TB) in a 47-year-old man who had been living with a dormant infection. This unprecedented immune response raises questions about how vaccines interact with underlying health conditions, particularly in immunocompromised individuals.
This article explores how the Covid booster reawakened TB, the science behind immune system reactions, and what this case means for future vaccination strategies.
The Unusual Case: Covid Booster Triggers Tuberculosis
A 47-year-old man in India had been living with latent tuberculosis—a silent infection that remains in the body without causing symptoms. Before his Covid vaccinations, he showed no signs of active TB and had tested negative for the disease during routine screenings.
However, things took a shocking turn after his third Covid booster shot. Within just five days, he began experiencing severe symptoms, including:
✔ High fever
✔ Excessive night sweats
✔ Extreme fatigue
✔ Painful swelling in his lymph nodes
Doctors initially suspected an autoimmune reaction, but further tests revealed that his dormant TB infection had become active, a rare occurrence known as tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS).
Understanding TB-IRIS: A Hyperactive Immune Response
What is TB-IRIS?
TB-IRIS is a condition where a weakened immune system suddenly regains strength and aggressively attacks a dormant TB infection, causing excessive inflammation. It is most commonly seen in HIV patients when they start antiretroviral therapy, but this case suggests that Covid vaccines could also trigger similar immune responses in some individuals.
Video : Covid booster vaccine reawakens world’s deadliest virus inside man’s body
How Did the Covid Vaccine Play a Role?
Covid mRNA vaccines are designed to stimulate the immune system by mimicking viral proteins. This triggers the body to produce a strong defense against potential infections. However, in rare cases, the immune system may become too aggressive and start attacking latent infections like TB, which had previously been controlled by the body.
The man’s immune system, reawakened by the Covid booster, mistakenly identified his dormant TB bacteria as a new threat, leading to a full-blown inflammatory response.
A Misdiagnosed Condition: The Road to Discovery
Before this incident, the patient had been diagnosed with rheumatoid arthritis (RA)—an autoimmune condition that causes chronic joint pain. To treat RA, he was prescribed immunosuppressive drugs, which weakened his immune system and may have allowed TB bacteria to remain inactive.
But when he received his Covid booster, the sudden immune reactivation overwhelmed his body, making the TB infection spread rapidly and causing severe inflammation.
Symptoms That Led to a TB Diagnosis
The man’s initial symptoms were mistakenly linked to arthritis and Covid vaccine side effects. However, as his condition worsened, doctors conducted further tests, revealing:
✔ Severe swelling in lymph nodes (especially in the neck)
✔ CT scan abnormalities indicating TB inflammation
✔ Biopsy confirming tuberculosis
He was immediately placed on a four-drug TB treatment plan, which led to significant improvement within five days.
A Second Shock: TB Symptoms Return After Third Booster
Just two weeks later, the man received his third Covid booster shot—and his TB symptoms returned even more aggressively.
🔴 Severe chills and fever
🔴 Uncontrollable night sweats
🔴 Extreme weakness
This time, doctors quickly identified TB-IRIS as the cause. His immune system had once again been overstimulated, leading to a dangerous inflammatory reaction.
How Was He Treated?
Doctors acted fast to control his immune response while keeping his TB treatment on track. His treatment plan included:
✔ High-dose intravenous (IV) steroids for five days to calm the immune system
✔ A slow transition to oral steroids for three months
✔ Continued TB medication for over a year
By his 18-month follow-up, his TB symptoms had fully disappeared, and he was finally able to resume arthritis treatment.
Video : A man deliberately got 217 Covid shots. Here’s what happened
What Does This Mean for Future Vaccinations?
This case does not mean that Covid vaccines cause tuberculosis. Instead, it highlights how vaccines can trigger unexpected immune responses in individuals with hidden or latent infections.
Key Takeaways for Patients with Immune Conditions:
🔹 Screening before vaccination: Patients with a history of autoimmune disorders, chronic infections, or immunosuppressive treatments should consult their doctors before getting a booster shot.
🔹 Monitoring for post-vaccine symptoms: If unusual symptoms occur after a vaccine, immediate medical attention is crucial to prevent severe complications.
🔹 Individualized vaccination approaches: Not everyone reacts to vaccines the same way. High-risk patients may require adjusted booster schedules or additional monitoring.
Other Inflammatory Reactions Linked to mRNA Vaccines
While mRNA vaccines are highly effective, there have been reports of immune-related side effects, including:
⚠️ Myocarditis (heart muscle inflammation)
⚠️ Pericarditis (inflammation around the heart lining)
⚠️ Autoimmune disease flare-ups in some individuals
This does not mean vaccines are dangerous, but rather that certain individuals with pre-existing immune conditions may need extra precautions when receiving booster shots.
Final Thoughts: A Rare but Important Medical Case
This case of TB reactivation after a Covid booster is an extremely rare occurrence, but it serves as a reminder of how complex the human immune system is.
While vaccines remain a crucial tool in fighting infectious diseases, this case highlights the importance of personalized medicine—tailoring vaccination plans to each individual’s unique health condition.
If you or someone you know has a history of autoimmune disease, chronic infections, or immune-related conditions, it’s always best to consult a doctor before receiving a booster shot. Awareness and proactive healthcare can prevent rare complications while still ensuring protection against deadly viruses.
What are your thoughts on this case? Have you or someone you know experienced an unusual immune reaction after a vaccine? Let us know in the comments!
Son Leaves Mom in Wheelchair on the Street, Year Later Sees Her Coming to His House on Her Feet – Story of the Day
Wendy hoped her son, John, would care for her in her sunset years. But John left her alone on the street. He did not expect his mother to appear at his doorstep a year later, standing on her feet.
“Can’t talk now, mom! I’m with a customer. I might finally sell a house this year. I’ll call the neighbors to check up on you. But I’m sure it’s nothing. You must’ve sat on the pot too long. Ok. Gotta go. I’ll come in to check on you tonight.”
Wendy remembered the call with her son, John, the first time her legs went numb. She remembered the state of panic she was in when she called him for help. She remembered getting breathless, fearing she was going to die. But her son did not have time to help her despite living a few blocks away.
He didn’t remember to call the neighbors to check in on her or visit her that night. And he even failed to sell the house, or any house, for that entire year.
For illustration purposes only. | Source: Getty Images
It had been a year since Wendy started feeling numbness in her legs. They stopped working all of a sudden as if they were paralyzed. Initially, the weakness in her legs lasted 10-15 minutes. She would wait it out by simply gathering herself and resting in the corner of the house until her legs came back to normal.
Eventually, the frequency of her legs going numb increased, until one day, when she had a fall and couldn’t get up. She cried for help, and luckily, the neighbors showed up. They informed John, who rushed in and took Wendy to the hospital.
Wendy was diagnosed with a rare nerve compression syndrome that caused numbness in her lower limbs. Her situation got complicated for over a year as she and John ignored her symptoms. And the injuries she sustained while falling made things worse.
Wendy was now in a wheelchair.
For illustration purposes only. | Source: Getty Images
John drove Wendy to the hospital and back for the first month of her physiotherapy sessions, but nothing helped Wendy get better. Although Wendy was spending her money for the treatment, John was getting frustrated, driving her to and fro.
“I think you should give up, mom. How many times am I supposed to miss my meetings? You know I need to focus on selling houses, right?” Wendy would wipe her tears while listening to her son’s insensitive comments during their car rides.
‘But he’s my son. At least he’s there for me,’ Wendy would console herself.
Karma will always hit you back.
After the physiotherapy and medication did not improve Wendy’s condition, the doctors suggested she get an expensive surgery. Wendy had spent all her savings on her treatment. She asked John for help, but he refused.
“Do you know how much rent I pay for my house? I can’t afford it, but as a realtor, I need to have a lifestyle. Who would buy a house from someone who lives in a small house?” John explained to Wendy.
For illustration purposes only. | Source: Getty Images
One day, John received a call from Wendy’s neighbors saying she was at the hospital for surgery. John did not know about any surgery, but he drove to the hospital.
He reached Wendy’s room and saw her sitting on her bed, crying while a group of doctors spoke to her. The primary doctor noticed John and came out of the room and said, “Are you Mr. John Matthews, her son?” John nodded.
“Where have you been? We waited for someone next of kin, but since no one arrived, we decided to deliver the news to Wendy directly.”
“What news?”
“Mr. Matthews, your mother’s surgery did not give the expected results. We still haven’t noticed any significant movement in her legs. And we can’t be sure when we will see a change. We’ll have to wait and watch for now. Wendy has already signed the discharge formalities and is free to go.”
For illustration purposes only. | Source: Getty Images
John feigned empathy for Wendy and consoled her. As he took her in the wheelchair towards his car, he asked her how she arranged for the money.
“I didn’t want to trouble you for any money, son, so I made the decision myself.”
“What decision, mom?”
“I sold the house.”
John stopped in his tracks, stunned.
“Remember Joanne? My friend from the old book club who moved to another city? She introduced me to her nephew, who wanted to buy a house in our area. Actually, they called and said they were coming here to visit me—”
“Are you kidding, mom? You sold the house? And for what, a failed surgery? You’re so selfish! You didn’t even think of me! It’s my house too, right? I was waiting on that house after—”
For illustration purposes only. | Source: Getty Images
John stopped himself, but Wendy realized what he meant. She was hurt that all John cared about was his inheritance and did not care about her.
Wendy was wiping her tears when John got a call from a prospective customer. He walked away to answer it. After his call, he told Wendy he had an urgent meeting with his customer.
“Go, son. As I said, Joanne was coming to visit me. I’ll ask her to drop me at the nursing home, and I have already spoken to them about moving there.”
“You see, that’s what I’m talking about. I had no idea what you do—”
John was interrupted by another call. He shook his head with disgust at his mother and just took off. Wendy was quietly sobbing on the street near the parking lot, feeling alone and hurt.
For illustration purposes only. | Source: Getty Images
A year had passed, and John hadn’t spoken with his mother. One morning, he heard a car pull up near his driveway. He wasn’t expecting visitors. He went out and saw a senior woman get out of the car. She stood outside the car, searching for something in the glove compartment.
“Can I help you, ma’am?” John asked, confused to see a stranger park outside his house.
When the woman turned around, John had the shock of his life. It was Wendy, and she was able to walk on her feet.
“Mom, oh my God! How are you?”
“Much better, son. I love every moment.” Wendy’s positive response took John aback, and he invited her to the house and offered her a glass of water.
John did not know how to interact with her. Wendy broke the ice and said, “Don’t look so gloomy, son. Look, I’m fine now. Remember when you left me all alone on the street after I was out after a failed surgery?” John turned pale as he recounted his behavior.
For illustration purposes only. | Source: Getty Images
“Well! My friend Joanne and her nephew, Evan, arrived shortly after that. They were heartbroken seeing me all alone near the parking lot, so they took me with them instead of dropping me at the nursing home. Joanne had to leave the next day, but Evan offered me to stay with him in my old house. I mean, his house since he bought it from me.”
“He cared for me like a son and even found better doctors in another city. I was afraid of another surgery, but Evan was there by my side throughout. And miraculously, the surgery worked. Evan also paid for my knee replacement surgery. Not only can I walk, but I can also run like I used to when I was young.”
John was speechless. Although he was embarrassed, he did not like how Wendy praised a stranger. He snarled, “I get it. I was a horrible son. But if this Evan is so great, why are you even here?”
John heard another car pull up outside his house. A young man walked into his house.
For illustration purposes only. | Source: Getty Images
“Oh, Evan. Great timing. We were just talking about you,” Wendy chuckled, greeting Evan.
“Excuse me. You can’t just enter my house like that.” John said, furiously pointing at Evan.
“Well, but I can enter MY house, can’t I?” Evan’s words confused John.
As it turned out, Evan owned the house Jonathan was living in. John was unaware since he only dealt with the agency that mediated all the transactions. Furthermore, John had skipped six months’ rent and evaded calls from the agency.
The agency notified Evan after John skipped rent for a couple of months. But Evan knew that John was struggling based on what he heard from Wendy, so he decided to go easy on John and asked the agency to back off, too.
But when Wendy learned about John’s antics, she realized that she couldn’t give him any more rope. She urged Evan to punish John for not paying the rent.
“Oh, I almost forgot, son!” Wendy reached into her bag. “Here is the eviction notice. You have 15 days.” Wendy handed John the documents and left with Evan.
For illustration purposes only. | Source: Getty Images
John sat on his couch and held his head. He realized that his behavior had finally led to him hitting rock bottom.
What can we learn from this story?
- Take care of your parents. Our parents sacrificed a lot to raise us; the least we can do for them in their old age is care for them. Wendy cared a lot for John even if he disrespected and hurt her. John never cared for Wendy when she needed him but still expected her house as an inheritance.
- Karma will always hit you back. John always treated Wendy with disdain and disrespect. His bad karma finally hit back when his mother decided to help evict him from his house.
Share this story with your friends. It might brighten their day and inspire them.
Leave a Reply