In a small Brazilian town, there resides an extraordinary duo of identical twins named Elis and Eloá. Their story serves as a beacon of resilience and the remarkable power of the human spirit. Afflicted with Hutchinson-Gilford Progeria Syndrome, a rare and fatal genetic disorder causing accelerated aging, these twins confront their adversities with remarkable grace and strength, earning admiration from people worldwide.
Understanding Hutchinson-Gilford Progeria syndrome
HGPS stands as an exceptionally rare disorder, impacting roughly 1 in 20 million newborns globally. Marked by rapid aging from early childhood, individuals with progeria often display growth delays, diminished body fat and hair, prematurely aged skin, joint stiffness, and severe cardiovascular issues. Typically, those with HGPS have an average life expectancy of about 14.5 years, though some may extend into their late teens or early twenties. This syndrome gained public attention through the film The Curious Case of Benjamin Button.
The condition is caused by a mutation in the LMNA gene, which produces the lamin A protein responsible for maintaining the structural integrity of the cell nucleus. The mutation results in the production of an abnormal version of the protein, called progerin, which causes cells to become unstable and die prematurely.
Elis and Eloá’s journey
Elis and Eloá swiftly captured attention because of their distinctive medical condition. Despite the physical hurdles imposed by progeria, their contagious smiles and steadfast optimism have emerged as beacons of hope and inspiration. Guilherme and Elismar, the twins’ parents, have dedicated their lives to offering the utmost care for their daughters, striving to ensure they experience as normal a life as feasible within the confines of their condition.
The family’s path has been far from easy. Their daily life is filled with demanding medical routines, including physiotherapy, aimed at addressing joint stiffness and preserving mobility. Despite these challenges, Elis and Eloá approach each day with remarkable bravery and an unparalleled enthusiasm for life, which is truly remarkable.
A global community of support
Elis and Eloá’s narrative has touched hearts worldwide, sparking a surge of solidarity from individuals and groups committed to promoting awareness about progeria and backing research endeavors. The Progeria Research Foundation, a pivotal entity in this realm, has played a vital role in propelling research forward and furnishing assistance to families grappling with the condition.
Through social media platforms, the twins’ journey is shared with a broad audience, fostering a sense of community and solidarity. Their family’s updates, documenting both the highs and lows of their daily lives, provide invaluable insights into the realities of living with progeria, while also spreading a message of hope and perseverance.
Advances in research and hope for the future
In recent years, there have been remarkable advancements in comprehending and addressing progeria. A notable milestone occurred in 2020 when the U.S. Food and Drug Administration (FDA) granted approval for the first progeria treatment: lonafarnib. This medication has demonstrated efficacy in prolonging the lives of children with progeria by mitigating the accumulation of progerin in cells, thereby decelerating the disease’s advancement.
Though a cure remains elusive, ongoing research presents promising prospects. Scientists are delving into gene-editing methodologies, like CRISPR, as potential means to rectify the genetic mutation at its root. For families such as Elis and Eloá’s, these breakthroughs offer a ray of hope for the future.
And in our other article, we recounted the remarkable story of a girl born without a nose, affectionately dubbed “Voldemort,” who refuses to let her differences define her.
My New Neighbors Invited Me Over, but All I Found Was an Abandoned Child with a Heartbreaking Note — Story of the Day
My new neighbors seemed odd from the start. Their little child played alone, and I ended up spending half the day with her until her mother finally appeared. Out of courtesy, she invited me over. The next day, I found the abandoned child with a heartbreaking note. I decided to act immediately.
It was a typical quiet day in our small suburban neighborhood when I noticed the moving truck pull up to the old house next door. The place had been abandoned for years, and seeing any activity there was surprising enough.
I stood at my window, peering through the curtains like a curious cat.
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“Who are they?” I muttered to myself, trying to make sense of what I was seeing.
The man was tall, with sharp features that made him look like he’d stepped out of a noir film.
The woman with him, though—she was something else. Pale, almost ghostly, with a distant look in her eyes as if she was there, but not really.
And then, there was the little girl.
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She couldn’t have been more than four years old. Tiny thing, with big eyes full of innocence, clutching a worn-out teddy bear as if it was her only friend in the world.
She played alone in the overgrown yard, her small figure seeming even smaller against the wild grass and tangled weeds.
What a strange family!
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Samuel and I had always dreamed of having kids. After years of trying, though, it became painfully clear that it wasn’t going to happen for us.
Samuel never talked much about it, always brushing it off with a shrug or a quick change of subject.
But me? I couldn’t let go of the dream. And seeing that little girl, so alone… It stirred something deep inside me.
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***
A few days later, I went for my usual walk around the neighborhood. As I turned the corner, there she was—the little girl from the neighbor’s house. This time, she was dangerously close to the street.
“Hey there, sweetie,” I called out gently, hurrying over. “Let’s not play so close to the road, okay?”
She looked up at me with wide, innocent eyes, and for a moment, I just stood there, holding her tiny hand.
I led her back toward her house and knocked on the door. No answer. My hand hesitated on the doorknob.
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Should I?
I took a deep breath and pushed it open, just a crack.
The house was almost empty, just a few old pieces of furniture and scattered boxes. It was like they’d moved in but hadn’t settled. Nobody was inside.
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“What’s your name, sweetie?” I asked, crouching down to the girl’s level.
“Lily,” she replied, her voice as soft as a whisper.
“Well, Lily,” I said, “how about we draw some pictures?”
“I have no crayons.”
Those words cut a hole in my heart.
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“Alrighty! Let’s use a stick and sand outside!” I tried to cheer her up.
She nodded eagerly, and I began tracing simple shapes with a wooden stick—a heart, a star, and the letter “A.” Lily watched closely, her eyes widening with each stroke of the stick.
“Can I try?” she asked, reaching for the stick.
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“Of course,” I handed it to her, “Why don’t you try writing your name?”
She carefully drew a shaky “L” in the dirt, then looked up at me for approval.
“That’s great, Lily! You’re doing such a good job!” I encouraged her.
After a while, we moved on to another game. I pointed to some stones nearby.
“Let’s build something together. How about a castle?”
“A castle! Yes!”
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We gathered the stones, stacking them one on top of the other. It was a simple structure, really, but to Lily, it seemed like the grandest thing in the world.
“Look, it’s like a tower,” she said, placing a small stone carefully on top.
“It is! And here’s another one for the other side,” I added, handing her a flat stone. “You know, this could be where the princess lives.”
Lily’s face lit up even more at the idea.
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“And the prince can live over here,” she said, pointing to a spot on the other side.
I noticed how intently Lily focused on the task as if each stone was a precious gem. It made me wonder if she had ever played with real toys before.
“Thank you for playing with me.”
My heart swelled at her words.
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As the sun began to set, I started to worry about what to do.
Finally, the girl’s mother appeared, almost out of nowhere. She seemed surprised to see me but didn’t show much emotion.
“Thanks,” she said flatly, taking the girl’s hand. “I was nearby all the time.”
There was no warmth, no smile—just those words. Before leaving, she added,
“Why don’t you come over for tea tomorrow?”
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It wasn’t so much an invitation as an obligation. But I nodded, agreeing anyway.
I glanced down at Lily. She had been so engaged, so full of life while we played, but the moment her mother appeared, something in her seemed to change.
“Lily, it’s time to go.”
Without a word, Lily simply walked over to her mother, her small hand slipping into the woman’s cold grasp. There was no protest, no hesitation—just quiet obedience.
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“Okay, Mommy.”
Lily looked back at me. “Will you come to play with me again?”
“Of course, sweetie,” I replied, my voice catching in my throat.
As I watched them disappear down the path, a sense of unease crept over me. That sadness in Lily’s eyes was like a silent plea, a cry for help that she couldn’t voice.
There was something off about this family—something I couldn’t quite put my finger on.
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***
The next day, I hesitated, staring at the chipped paint on the neighbor’s door, then knocked. No answer. I knocked again, louder this time, but still nothing.
“Hello? It’s me, from next door,” I called out, hoping to hear some sign of life inside.
Nothing. The house remained eerily quiet, the silence pressing down on me like a weight. After what felt like an eternity, I hesitantly pushed the door open and stepped inside.
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“Hello?”
My footsteps sounded loud against the wooden floor as I wandered through the rooms, each one emptier than the last.
Then, in the living room, I found Lily. She was sitting on the floor with a pack of cookies and a bottle of water. She was holding a piece of paper in her tiny hands.
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“Lily?” I whispered, kneeling beside her.
She didn’t say anything, just handed me the note. I unfolded the paper, the heartbreaking message inside sending a cold chill down my spine:
“She’s yours if you want her. We know you’ll take good care of her.”
I stared at the words, my mind racing.
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Who would do such a thing? Abandon their child like this, leaving her in an empty house with nothing but a note?
Panic started to rise in my chest, and I grabbed Lily, pulling her close.
“We need to go,” I whispered, scooping her up into my arms.
As I headed for the door, a terrifying thought crossed my mind.
What if this was a trap?
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I froze for a moment, my heart pounding. But then I looked down at Lily. I couldn’t leave her there, no matter the risks.
When we arrived back at my house, Samuel was already home. He looked up from the couch as I walked in.
“What is this?” he demanded.
I set Lily down gently and handed her a box of crackers and a glass of milk.
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“Here, sweetie, why don’t you have a snack and watch some cartoons?” I said, turning on the TV to distract her.
Once she was settled, I turned back to Samuel, who was now standing, his face twisted with anger.
“Why is there a child in our house, Eliza?” he raised his voice.
“Samuel, I found her alone,” I began, my voice trembling. “In that empty house, with nothing but this note.”
I handed him the paper. He read the note quickly, then looked up at me.
“You’ve broken our agreement, Eliza. We agreed—no children in this house!”
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“Samuel, I couldn’t just leave her there! She was all alone, with no one to take care of her,” I pleaded, trying to make him understand.
But his anger only grew.
“I told you I didn’t want kids! And now you’ve brought one into our home? Do you even realize what you’ve done?”
His words cut deep, like a knife twisting in my chest.
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“You never said that! All these years, you said it was because of your health…”
He looked away, his jaw clenched.
“I lied. I never wanted children, Eliza. I just didn’t want to lose you.”
It felt like the ground had been pulled out from under me. All those years, all those hopes and dreams… I had been living a lie.
Samuel delivered his ultimatum:
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“Either you take her back, or go away.”
I stared at him, the man I had loved and trusted, and realized that I couldn’t stay. Not like this. Not with him.
Without another word, I turned away from him, gathering a few belongings. I packed a small bag, trying to hold back the tears that threatened to spill over.
I couldn’t abandon Lily after everything she had already been through.
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As I took Lily’s hand and led her to the door, Samuel didn’t stop me. He just stood there, cold and distant, as if we were strangers.
I had no idea where we would go.
Finally, we ended up at the school where I work and spent the night in my office. I knew it wasn’t a permanent solution, but it was a start.
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***
In the following days, I began the adoption process for Lily, but it wasn’t easy. The authorities insisted I needed a stable home.
Then, unexpectedly, they informed me that Lily’s biological parents had left her an inheritance — the house. So, I could adopt Lily and move in there.
Shocked, I dug deeper and discovered that Lily’s foster parents — my neighbors — had adopted Lily solely for that inheritance. But realizing they couldn’t care for her, they decided she deserved better.
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To ensure she wouldn’t end up in another home for the wrong reasons, they left her, and the house, in my care. We moved in the same day, and the house became our home, filled with warmth and love.
Lily slowly opened up, and every time she called me “Mommy,” my heart swelled.
Samuel, living alone, began to reconsider his choices. He started helping around the house and taking care of Lily when I was busy. Forgiving him wasn’t easy, but his efforts made me feel that maybe we could find our way back to each other.
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If you enjoyed this story, read this one: My husband was cheating on me with my boss, and I silently endured it. Then, my boss handed me tickets to distant islands, clearly with her own agenda. At the airport, I found myself fighting for a taxi. Little did I know, that chaotic moment would mark the beginning of an unexpected love story.
This piece is inspired by stories from the everyday lives of our readers and written by a professional writer. Any resemblance to actual names or locations is purely coincidental. All images are for illustration purposes only. Share your story with us; maybe it will change someone’s life.
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