“Don’t stay out too late. And remember, homework first when you get back,” I called after him as he stormed out the door, not waiting for my reply.
It was just another day in the life I’d been patching together since Silas left. Balancing the responsibilities of raising two kids alone while trying to keep a roof over our heads wasn’t easy.
My work at the call center helped, but it wasn’t exactly my dream job. It was a job, though, and in times like these, that’s all that mattered.
That’s when Emery, the new neighbor in her early 30s, knocked on my door. I opened it to see her, eyes red-rimmed, looking like she hadn’t slept in days.
“Hey, Prudence, can I ask you for a huge favor?” she said, her voice cracking slightly.
I nodded, stepping aside to let her in. “Sure, Emery. What’s going on?”
She sighed, sinking into the couch like she was about to collapse. “I had this crazy party last night, and then I got called out of town for work. The place is a disaster, and I don’t have time to clean it up. Could you, um, help me out? I’ll pay you, of course.”
I hesitated, glancing at the clock. My shift was due to start in a couple of hours, but the idea of earning some extra cash was tempting. Lord knows we could use it.
“How much are we talking about?” I asked, folding my arms across my chest.
“Two hundred and fifty dollars,” she said quickly. “I just really need the help, Prudence. I wouldn’t ask if it wasn’t an emergency.”
“Alright,” I agreed after a moment. “I’ll do it.”
“Thank you so much! You’re a lifesaver!” Emery hugged me quickly before rushing out, leaving me to wonder what I’d just signed up for.
Emery’s house was a wreck, and that’s putting it mildly. It looked like a tornado had blown through it, with empty bottles, plates with half-eaten food, and trash strewn everywhere.
I stood in the middle of her living room, hands on my hips, trying to figure out where to even begin.
Two days. It took me two solid days of scrubbing, sweeping, and hauling garbage out of that house. By the time I was done, my back ached, and my hands were raw. But I kept reminding myself of that $250 Emery promised. That money would go a long way for us.
When Emery finally got back, I marched over to her place, ready to collect.
“Emery, it’s done. Your house is spotless,” I said, trying to keep the exhaustion out of my voice. “So, about the payment…”
She blinked at me like I was speaking another language. “Payment? What payment?”
I frowned, my heart sinking a little. “The $250 you promised for cleaning up your house. Remember?”
Emery’s expression shifted into one of confusion, then annoyance. “Prudence, I never agreed to pay you anything. I don’t know what you’re talking about.”
For a moment, I just stood there, dumbfounded. “You… what? You said you’d pay me! We had an agreement.”
“No, we didn’t,” she snapped. “Look, I’m late for work, and I really don’t have time for this.” She pushed past me, heading towards her car.
“Emery, this isn’t right!” I called after her, but she was already backing out of her driveway, not giving me a second glance.
As I watched Emery’s car disappear down the street, I stood there, fuming. How could she just walk away like that?
Two days of back-breaking work, and she had the nerve to pretend like we never made a deal. I could feel my anger bubbling up, but I knew better than to act on impulse.
I went back to my house, slammed the door behind me, and paced the living room, trying to think. Connie was playing with her dolls on the floor, and Damien was still out with his friends. I didn’t want to drag my kids into this mess, but I also wasn’t about to let Emery get away with it.
“Alright, Prudence, you’ve got to be smart about this,” I muttered to myself. I looked out the window at Emery’s house and an idea started to form in my mind. It was risky, but I was beyond caring at that point. If she wanted to play dirty, I could get down in the mud too.
Twenty minutes later, I was at the local garbage dump, pulling on a pair of old gloves I kept in the car. I wasn’t proud of what I was about to do, but desperate times called for desperate measures.
I loaded up my trunk with as many garbage bags as I could fit, the stench nearly making me gag. But I gritted my teeth and kept going.
On the drive back, I kept replaying our conversation in my head, her dismissive tone, her refusal to acknowledge what she’d promised. The more I thought about it, the more justified I felt.
She didn’t even have the decency to respect the hard work I’d put into cleaning her filthy house. Well, she was about to see just how dirty things could get.
When I pulled up in front of Emery’s house, the street was quiet. No one was around to see me pop the trunk and start hauling the garbage bags to her front door. My heart pounded in my chest, adrenaline coursing through me as I worked quickly.
It was then I realized something: Emery had forgotten to take her house key back from me. She was in such a hurry when she left, she didn’t even think about it.
I hesitated for a moment. But then I thought of the look on her face when she told me there was no agreement, the way she dismissed me like I was nothing. I wasn’t going to let her get away with it.
I unlocked the door and stepped inside. The house was still spotless, just as I’d left it, but that was about to change. One by one, I tore open the garbage bags, dumping the contents all over her floors, her counters, and even her bed. Rotten food, old newspapers, dirty diapers: everything mixed in a disgusting heap.
“This is what you get, Emery,” I muttered under my breath as I emptied the last bag. “You wanted to play games, well, game on.”
I closed the door behind me, making sure to lock it, and slipped the key under her welcome mat. As I walked back to my car, I felt a strange surge of satisfaction and guilt. But I shook it off. Emery had brought this on herself.
That evening, just as I was putting Connie to bed, I heard furious banging on my front door. I knew who it was before I even opened it.
“Prudence! What the hell did you do to my house?!” Emery screamed, her face red with anger.
I crossed my arms and leaned against the doorframe, playing it cool. “I don’t know what you’re talking about, Emery. How could I have gotten into your house? We never had any agreement, remember? So, I never had the keys to your house.”
She stared at me, speechless for a moment, before her face twisted in rage. “You—you’re lying! I’m calling the police! You’re going to pay for this!”
I shrugged, not breaking eye contact. “Go ahead and call them. But how are you going to explain how I got in? You can’t because according to you, I never had the key.”
Emery opened her mouth to argue, but no words came out. She looked like she was about to explode, but all she could do was turn on her heel and storm off, muttering something under her breath.
I watched her go, my heart still pounding, but this time it wasn’t just from anger. There was a sense of justice, of balance restored.
I didn’t know if she’d call the police, but I wasn’t worried. Emery had learned a valuable lesson that day: don’t mess with Prudence.
As I closed the door, I let out a long breath, feeling a weight lift off my shoulders. I knew I’d crossed a line, but in that moment, it felt like the only way to make things right.
Sometimes, you have to stand up for yourself, even if it means getting your hands dirty. And as for Emery? Well, I had a feeling she wouldn’t be asking me for any more favors anytime soon.
Do you think I handled things well? What would you have done differently in my place?
We’ve All Waited for It: Scientists Created a Drug That Can Help Regrow Lost Teeth
The tooth fairy is a welcome guest for any child who has lost a tooth. Not only will the fairy leave a small gift under the child’s pillow, but they be assured of a replacement tooth in a few months. Unfortunately, the scenario is quite different for adults grappling with a loss of teeth. Luckily, there may be some hope thanks to a new study performed by scientists at Kyoto University and the University of Fukui.
A dental breakthrough
While the typical adult mouth houses 32 teeth, approximately 1% of the population exhibits variations of them, either possessing more or fewer teeth due to congenital conditions. Researchers have delved into the genetic factors behind cases of excessive teeth, seeking valuable insights into the potential regeneration of teeth in adults. This study is the first to show that monoclonal antibodies can help regrow teeth. It suggests a new way to treat a dental problem that currently requires implants and other artificial solutions.
A bit of science
The research team disclosed that an antibody targeting a specific gene, known as uterine sensitization-associated gene-1 (USAG-1), can induce tooth development in mice affected by tooth agenesis, a congenital condition. The findings were published in the journal, Science Advances.
As per Katsu Takahashi, a senior lecturer at the Kyoto University Graduate School of Medicine and one of the principal contributors to the study, the essential molecules crucial for the development of teeth have already been pinpointed. “The morphogenesis of individual teeth depends on the interactions of several molecules including BMP, or bone morphogenetic protein, and Wnt signaling,” says Takahashi.
On April 13, 2021, the University of Kyoto posted its first pic of newly-grown teeth in mice.
BMP and Wnt are involved in more than just tooth development; they affect the growth of organs and tissues early in the body’s development. Because drugs affecting them directly might have broad side effects, scientists are cautious. To find a potentially safer method, researchers focused on the gene USAG-1, thinking that aiming at factors countering BMP and Wnt specifically in tooth development could be more precise.
“We knew that suppressing USAG-1 benefits tooth growth. What we did not know was whether it would be enough,” added Takahashi.
The first results
Scientists looked at how different monoclonal antibodies affect USAG-1. Monoclonal antibodies are often used to treat things like cancer and arthritis and for making vaccines. Tests with this antibody showed that BMP signaling is crucial for deciding the number of teeth in mice. Also, just one treatment was enough to grow a whole tooth. Further tests confirmed these positive results in ferrets too.
“Ferrets are diphyodont animals with similar dental patterns to humans. Our next plan is to test the antibodies on other animals, such as pigs and dogs,” explained Takahashi.
Fully regrown frontal teeth in ferrets
The next steps
Now, scientists are going to test the drug on healthy adults. If that goes well, the team plans to try it on kids aged 2 to 6 with a rare tooth problem called anodontia, a genetic disorder defined as the absence of all teeth. These kids will get one shot of the drug to see if it makes their teeth grow. If everything works out, the medicine might be approved by 2030.
Takahashi sees the new medicine as an additional choice for individuals who are missing some or all of their teeth.
“The idea of growing new teeth is every dentist’s dream,” Takahashi told the Japanese newspaper, The Mainichi in June this year. “I’ve been working on this since I was a graduate student. I was confident I’d be able to make it happen.”
So hopefully, by the year 2030, humans will get a chance to have their third generation of teeth grown and say goodbye to implants. Until then, make sure to keep your teeth strong and healthy — this article will help you with that.
Preview photo credit KyotoU_News / Twitter
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